Continuous monitoring of biomarkers at locations adjacent to targeted internal organs can provide actionable information about postoperative status beyond conventional diagnostic methods. As an example, changes in pH in the intra-abdominal space after gastric surgeries can serve as direct indicators of potentially life-threatening leakage events, in contrast to symptomatic reactions that may delay treatment. Here, we report a bioresorbable, wireless, passive sensor that addresses this clinical need, designed to locally monitor pH for early detection of gastric leakage. A pH-responsive hydrogel serves as a transducer that couples to a mechanically optimized inductor-capacitor circuit for wireless readout. This platform enables real-time monitoring of pH with fast response time (within 1 hour) over a clinically relevant period (up to 7 days) and timely detection of simulated gastric leaks in animal models. These concepts have broad potential applications for temporary sensing of relevant biomarkers during critical risk periods following diverse types of surgeries.

中文翻译：

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可生物吸收、无线、无源传感器，用于连续 pH 测量和早期检测胃渗漏

连续监测目标内脏器官附近位置的生物标志物可以提供超越传统诊断方法的术后状态的可操作信息。例如，胃手术后腹腔内 pH 值的变化可以作为潜在危及生命的渗漏事件的直接指标，而不是可能延迟治疗的症状反应。在这里，我们报告了一种可生物吸收、无线、无源传感器，可以满足这一临床需求，旨在局部监测 pH 值，以便及早发现胃漏。 pH 响应水凝胶充当传感器，耦合到机械优化的电感电容电路以实现无线读出。该平台能够在临床相关期间（长达 7 天）内以快速响应时间（1 小时内）实时监测 pH 值，并及时检测动物模型中的模拟胃漏。这些概念对于在不同类型的手术后的关键风险时期临时感测相关生物标志物具有广泛的潜在应用。