Solute carriers (SLCs) control the flow of small molecules and ions across biological membranes. Over the last 20 years, the pace of research in SLC biology has accelerated markedly, opening new opportunities to treat metabolic diseases, cancer and neurological disorders. Recently, new families of atypical SLCs, with roles in organelle biology, metabolite signaling and trafficking, have expanded their roles in the cell. This Perspective discusses work leading to current advances and the emerging opportunities to target and modulate SLCs to uncover new biology and treat human disease.

中文翻译：

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溶质载体结构生物学的未来机遇

溶质载体 (SLC) 控制小分子和离子穿过生物膜的流动。过去 20 年来，SLC 生物学的研究步伐显着加快，为治疗代谢性疾病、癌症和神经系统疾病开辟了新的机会。最近，非典型 SLC 的新家族在细胞器生物学、代谢信号传导和运输中发挥作用，扩大了它们在细胞中的作用。本视角讨论了导致当前进展的工作以及针对和调节 SLC 以发现新生物学和治疗人类疾病的新机会。