Herein we report the synthesis of a ferroelectric composed of chitosan (C)/barium titanate (BT) nanoparticles (NPs) with enhanced biocompatibility, non-toxicity, and piezoelectric behavior that can be advantageously used in biomedical applications. FTIR and SEM measurements were performed to assess the mechanism of interaction between the C matrix and BT NPs and their correlation with the biological responses. The dielectric measurements of the as-prepared composites reveal that incorporation of 50% BT NPs in the chitosan matrix leads to a steady increase of the dielectric constant as compared with neat chitosan films. The ferroelectric behavior of the sample was confirmed by the values of the loss factor (0.21–0.003) in the analyzed frequency range (10⁻¹–10⁶ Hz). This behavior suggests that ferroelectric C/BT nanocomposites can act as an active material that promotes accelerated bone regeneration.

中文翻译：

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使用壳聚糖/钛酸钡铁电复合材料进行骨再生的生物物理刺激

在此，我们报道了由壳聚糖（C）/钛酸钡（BT）纳米颗粒（NP）组成的铁电体的合成，该铁电体具有增强的生物相容性、无毒性和压电行为，可有利地用于生物医学应用。进行 FTIR 和 SEM 测量以评估 C 基质和 BT NP 之间的相互作用机制及其与生物反应的相关性。所制备的复合材料的介电测量表明，与纯壳聚糖薄膜相比，在壳聚糖基质中掺入 50% BT NP 会导致介电常数稳定增加。样品的铁电行为通过分析频率范围（10 ^-1 –10 ⁶ Hz）内的损耗因子值（0.21–0.003）得到证实。这种行为表明铁电 C/BT 纳米复合材料可以充当促进加速骨再生的活性材料。