ImportanceHirsutism represents a significant concern for women with polycystic ovary syndrome (PCOS), with deleterious psychological effects warranting acknowledgment and a clear imperative to provide effective management. To our knowledge, this is the first review to exclusively examine the effectiveness of laser and light-based therapies in addressing hirsutism in women with PCOS.ObjectiveTo synthesize the existing literature regarding the effectiveness of laser and light hair reduction therapies, either as stand-alone treatments or in combination with systemic agents, in treating hirsutism for women with PCOS.Evidence ReviewA systematic literature review was performed using MEDLINE, Embase, EMCARE, and CINAHL according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines. Articles written in English, reporting on patients who met pre-established inclusion criteria were selected. Objective and subjectively measured outcomes relating to the effect of laser or light-based hair reduction therapies on hirsutism were abstracted. Heterogeneity among included studies precluded a meta-analysis, necessitating a narrative synthesis.FindingsSix studies reporting data on 423 individual patients with PCOS who underwent laser or light-based hair reduction therapies were included: 4 randomized clinical trials and 2 cohort studies. Alexandrite laser demonstrated significant improvements in hirsutism severity and psychological outcomes, particularly at high-fluence application. Alexandrite laser was also found to be more effective than intense pulsed light (IPL). The combination of diode laser with either metformin or combined oral contraceptive pill was superior to the application of diode laser alone, just as the addition of metformin to IPL demonstrated superior results to IPL treatment alone. Overall, most interventions were well tolerated. The overall certainty of evidence across all outcomes and comparisons was limited in part due to the observational nature of some studies.Conclusions and RelevanceThis systematic review highlights the potential of laser and light hair reduction therapies, both as stand-alone treatments and in combination with other pharmacological agents in PCOS. However, this review was limited by low certainty of the evidence, few studies evaluating effectiveness and safety in those with skin of color, and heterogeneity in outcome assessment. Future studies are needed to provide more robust evidence among diverse individuals with PCOS and hirsutism.

中文翻译：

---

激光和光疗法治疗多囊卵巢综合症女性的多毛症

重要性 多毛症是患有多囊卵巢综合征 (PCOS) 的女性的一个重大问题，其有害的心理影响值得承认，并且明确必须提供有效的治疗。据我们所知，这是第一篇专门研究激光和光疗法在解决多囊卵巢综合征女性多毛症方面的有效性的综述。目的综合关于激光和光脱毛疗法（无论是单独使用）的有效性的现有文献治疗或与全身药物联合治疗 PCOS 女性多毛症。证据审查根据系统审查和荟萃分析的首选报告项目，使用 MEDLINE、Embase、EMCARE 和 CINAHL 进行了系统文献审查（棱镜) 报告指南。选择用英文撰写的文章，报告符合预先制定的纳入标准的患者。提取了与激光或光脱毛疗法对多毛症的影响相关的客观和主观测量结果。纳入研究之间的异质性排除了荟萃分析，因此需要进行叙述性综合。结果 六项研究报告了 423 名接受激光或光脱毛疗法的 PCOS 患者的数据：4 项随机临床试验和 2 项队列研究。紫翠玉激光显示出对多毛症严重程度和心理结果的显着改善，特别是在高通量应用中。紫翠玉激光也被发现比强脉冲光 (IPL) 更有效。二极管激光与二甲双胍或复方口服避孕药的组合优于单独应用二极管激光，正如在 IPL 中添加二甲双胍所证明的效果优于单独 IPL 治疗的效果。总体而言，大多数干预措施的耐受性良好。由于一些研究的观察性质，所有结果和比较的证据的总体确定性受到限制。结论和相关性本系统综述强调了激光和光脱毛疗法的潜力，无论是作为独立疗法还是与其他疗法相结合PCOS 的药物。然而，该综述受到证据质量低、很少有研究评估有色皮肤患者的有效性和安全性以及结果评估的异质性的限制。未来的研究需要为患有多囊卵巢综合症和多毛症的不同个体提供更强有力的证据。