White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old,Alzheimer's & Dementia

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White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2024-04-17 , DOI: 10.1002/alz.13816
Lisa C. Silbert _{1,

2} , Natalie E. Roese ₁ , Victoria Krajbich ₃ , Justin Hurworth ₁ , David Lahna ₁ , Daniel L. Schwartz _{1,

4} , Hiroko H. Dodge ₅ , Randall L. Woltjer _{1,

3}

Affiliation

Age-related magnetic resonance imaging (MRI) T2 white matter hyperintensities (WMHs) are common and associated with neurological decline. We investigated the histopathological underpinnings of MRI WMH and surrounding normal appearing white matter (NAWM), with a focus on astroglial phenotypes.

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