Ultrasound neuromodulation is a potential alternative therapy for suppressing epileptic discharges. Recently, several human clinical trials have reported promising results from repeated focused ultrasound (FUS) treatments for temporal lobe epilepsy. In this Viewpoint, we highlight the valuable guidance of preclinical validation methods for choosing the optimal FUS parameters, thus ensuring consistency with the outcomes of clinical trials and leading human trials to the safest and most effective approaches.

中文翻译：

---

神经调节聚焦超声治疗癫痫：动物模型有用吗？

超声神经调节是抑制癫痫放电的潜在替代疗法。最近，多项人体临床试验报告了重复聚焦超声（FUS）治疗颞叶癫痫的可喜结果。在本观点中，我们强调临床前验证方法对于选择最佳 FUS 参数的宝贵指导，从而确保与临床试验结果的一致性，并引导人体试验采用最安全、最有效的方法。