Transarterial chemoembolization (TACE) is widely recognized as a non-surgical treatment approach for advanced liver cancer, combining chemotherapy with the blockage of blood vessels supplying the tumor. To enhance the efficacy of TACE and address chemotherapy resistance, there is growing interest in the development of multifunctional embolic microspheres. In this study, multifunctional PVA microspheres, which encapsulate MIT as a chemotherapeutic drug, PPY as a photothermal agent, and Fe₃O₄ as a chemodynamic therapy agent, were prepared successfully. The results demonstrated that the developed multifunctional PVA microspheres not only exhibit favorable drug release, photothermal therapy, and chemodynamic therapy performance, but also show a promising synergistic therapeutic effect both in vitro and in vivo. Consequently, the engineered multifunctional PVA microspheres hold tremendous promise for enhancing TACE effectiveness and have the potential to overcome limitations associated with traditional liver cancer treatments.

中文翻译：

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工程聚乙烯醇微球能够用于光热/化学动力学治疗以增强经动脉化疗栓塞

经动脉化疗栓塞（TACE）被广泛认为是晚期肝癌的一种非手术治疗方法，将化疗与阻塞肿瘤血管相结合。为了提高 TACE 的疗效并解决化疗耐药问题，人们对开发多功能栓塞微球越来越感兴趣。本研究成功制备了包埋MIT作为化疗药物、PPY作为光热剂、Fe ₃ O ₄作为化学动力学治疗剂的多功能PVA微球。结果表明，所开发的多功能PVA微球不仅具有良好的药物释放、光热治疗和化学动力学治疗性能，而且在体外和体内表现出良好的协同治疗效果。因此，工程化多功能 PVA 微球在增强 TACE 有效性方面具有巨大前景，并有可能克服传统肝癌治疗的局限性。