The onset of Alzheimer's disease is related to neuron damage caused by massive deposition of Aβ in the brain. Recent studies suggest that excessive Aβ in the brain mainly comes from peripheral blood, and BBB is the key to regulate Aβ in and out of the brain. In this study, we explored the pathogenesis of AD from the perspective of Aβ transport through the BBB and the effect of QKL injection in AD mice. The results showed that QKL could improve the cognitive dysfunction of AD mice, decrease the level of Aβ and Aβ transporter—RAGE, which was supported by the results of network pharmacology, molecular docking and molecular dynamics simulation. In conclusion, RAGE is a potential target for QKL's therapeutic effect on AD.

中文翻译：

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QKL 注射通过调节 RAGE 的表达改善阿尔茨海默病样病理学

阿尔茨海默病的发病与大脑中Aβ大量沉积引起的神经元损伤有关。最近的研究表明，大脑中过量的Aβ主要来自于外周血液，而血脑屏障是调节Aβ进出大脑的关键。在本研究中，我们从Aβ通过血脑屏障的转运以及QKL注射对AD小鼠的影响的角度探讨了AD的发病机制。结果表明，QKL可以改善AD小鼠的认知功能障碍，降低Aβ和Aβ转运蛋白RAGE的水平，这得到了网络药理学、分子对接和分子动力学模拟结果的支持。总之，RAGE是QKL治疗AD的潜在靶点。