Accelerated biological ageing is a major underlying mechanism of frailty development. This study aimed to investigate if the biological age measured by a blood biochemistry-based ageing clock is associated with frailty in geriatric rehabilitation inpatients. Within the REStORing health of acutely unwell adulTs (RESORT) cohort, patients' biological age was measured by an ageing clock based on completed data of 30 routine blood test variables measured at rehabilitation admission. The delta of biological age minus chronological age (years) was calculated. Ordinal logistic regression and multinomial logistic regression were performed to evaluate the association of the delta of ages with frailty assessed by the Clinical Frailty Scale. Effect modification of Cumulative Illness Rating Scale (CIRS) score was tested. A total of 1187 geriatric rehabilitation patients were included (median age: 83.4 years, IQR: 77.7–88.5; 57.4 % female). The biochemistry-based biological age was strongly correlated with chronological age (Spearman = 0.883). After adjustment for age, sex and primary reasons for acute admission, higher biological age (per 1 year higher in delta of ages) was associated with more severe frailty at admission (OR: 1.053, 95 % CI:1.012–1.096) in patients who had a CIRS score of <12 not in patients with a CIRS score >12. The delta of ages was not associated with frailty change from admission to discharge. The specific frailty manifestations as cardiac, hematological, respiratory, renal, and endocrine conditions were associated with higher biological age. Higher biological age was associated with severe frailty in geriatric rehabilitation inpatients with less comorbidity burden.

中文翻译：

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通过先进的深度学习技术开发的基于血液生化的较高生物年龄与老年康复住院患者的虚弱有关：RESORT

加速生物衰老是衰弱发展的一个主要潜在机制。本研究旨在调查基于血液生化的衰老时钟测量的生物年龄是否与老年康复住院患者的虚弱有关。在急性不适成人恢复健康 (RESORT) 队列中，患者的生物年龄是通过老化时钟测量的，该时钟基于康复入院时测量的 30 项常规血液检查变量的完整数据。计算生物学年龄减去实足年龄（岁）的差值。进行序数逻辑回归和多项逻辑回归来评估年龄增量与临床衰弱量表评估的衰弱之间的关联。测试了累积疾病评定量表（CIRS）评分的效果修改。总共纳入了 1187 名老年康复患者（中位年龄：83.4 岁，IQR：77.7-88.5；57.4% 为女性）。基于生物化学的生物年龄与实际年龄密切相关（Spearman = 0.883）。调整年龄、性别和急性入院的主要原因后，对于以下患者，较高的生物学年龄（年龄增量每增加 1 年）与入院时更严重的虚弱相关（OR：1.053，95 % CI：1.012-1.096）。 CIRS 评分 <12 的患者不包括 CIRS 评分 >12 的患者。年龄增量与从入院到出院的虚弱变化无关。心脏、血液、呼吸、肾脏和内分泌疾病等特定的虚弱表现与较高的生物学年龄相关。较高的生物学年龄与合并症负担较少的老年康复住院患者的严重虚弱有关。