Since 2020, human pharmaceuticals were included in the list of emerging contaminants from the UNESCO and their detection and elimination were incorporated in the 2030 Agenda for Sustainable Development Goal Targets. Among these, analgesic and antipyretic drugs are the most widely used drugs worldwide and, despite their advantages, unused or expired pharmaceuticals are a potential source of water pollution. Paracetamol is one of the most common drugs used for analgesic and antipyretic purposes and has been found to have a much higher concentration in water streams in many European countries. Considering that, an all-in-one paper-based 2 dimensional (2D) fluidic configuration, able to detect paracetamol, was developed in order to deal with environmental matrices without complex/expensive analytical procedures. An ad-hoc paper-based testing area, coupled with a channel was designed and wax-printed onto a porous filter paper. Successively three electrodes were screen-printed, and the whole system was applied for the detection of paracetamol in wastewaters (prior and after the filtration system) without pretreating the sample. In order to detect paracetamol with the easiest approach, the configuration of the paper-based device was optimized in terms of type of substrate used for printing, microfluidic paper strip length/width and combination of them in an integrated architecture, capable to detect paracetamol in the matrices tested in few seconds with a detection limit down to micromolar range, ca. 1 μM. The integrated device shown great promise for simple, fast, sensitive, and sustainable detection of paracetamol in its role of emerging contaminant, especially in the environmental matrices.

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基于纸质的二维配置，用于电化学和简便地检测废水中的扑热息痛

自2020年起，人类药品被列入联合国教科文组织新兴污染物清单，其检测和消除被纳入2030年可持续发展目标议程。其中，镇痛药和解热药是全世界使用最广泛的药物，尽管有其优点，但未使用或过期的药物是水污染的潜在来源。扑热息痛是最常用的镇痛和解热药物之一，在许多欧洲国家的水流中发现其浓度要高得多。考虑到这一点，开发了一种能够检测扑热息痛的一体化纸质二维 (2D) 流体配置，以便无需复杂/昂贵的分析程序即可处理环境基质。设计了一个特设的纸质测试区域和一个通道，并将其蜡印到多孔滤纸上。连续丝网印刷三个电极，整个系统用于检测废水中的扑热息痛（过滤系统之前和之后），无需对样品进行预处理。为了以最简单的方法检测扑热息痛，纸基设备的配置在用于打印的基材类型、微流控纸条长度/宽度以及它们在集成架构中的组合方面进行了优化，能够检测扑热息痛基质在几秒钟内完成测试，检测限低至微摩尔范围，约 100%。 1μM。该集成装置在简单、快速、灵敏和可持续地检测对乙酰氨基酚作为新兴污染物（尤其是在环境基质中）的作用方面显示出巨大的前景。