INTRODUCTIONAlzheimer's disease (AD) is characterized by cognitive impairments; however, heightened anxiety often accompanies and, in some cases, exacerbates cognitive its. The present study aims to understand the influence of multiple variables on anxiety‐like behavior in TgF344‐AD rats and determine whether anxiety impacts memory performance.METHODSAn elevated plus maze was used to assess anxiety‐like behavior in the established colony (n = 107). Influences of age, sex, genotype, and exercise on anxiety were evaluated via multiple linear regression. Correlation analysis evaluated the relationship between anxiety and memory performance.RESULTSAge (P < 0.05) and AD genotype (P < 0.001) were associated with increasing anxiety, while exercise (P < 0.05) was associated with decreasing anxiety. Female AD animals displayed more anxiety‐like behavior versus wild‐type female (P < 0.001) and AD male (P < 0.05) littermates.DISCUSSIONConcluding that while factors such as age, sex, AD genotype, and training status can impact anxiety levels in the TgF344‐AD model, anxiety level did not impact memory performance.Highlights Increased anxiety‐like behavior in TgF344‐AD rats does not correlate with declines in memory performance. Predictors of higher anxiety‐like behaviors in the TgF344‐AD rat include age, Alzheimer's disease (AD) genotype, and sex with female AD animals experiencing greater anxiety compared to female wild‐type or male AD. Exercise training leads to decreased anxiety‐like behaviors in the TgF344‐AD rat.

中文翻译：

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阿尔茨海默病大鼠的焦虑与记忆无关，并受基因型、年龄、性别和运动的影响

简介 阿尔茨海默病 (AD) 的特点是认知障碍；然而，焦虑的加剧往往伴随着认知障碍，在某些情况下甚至会加剧认知障碍。本研究旨在了解多个变量对 TgF344-AD 大鼠焦虑样行为的影响，并确定焦虑是否影响记忆表现。方法采用高架十字迷宫评估已建立的群体中的焦虑样行为（n= 107）。通过多元线性回归评估年龄、性别、基因型和运动对焦虑的影响。相关分析评估焦虑与记忆表现之间的关系。结果Age (磷< 0.05) 和 AD 基因型 (磷< 0.001) 与焦虑增加相关，而运动 (磷< 0.05）与焦虑的减少有关。与野生型雌性相比，雌性 AD 动物表现出更多类似焦虑的行为（磷< 0.001) 和 AD 男性 (磷< 0.05) 同窝仔鼠。讨论得出的结论是，虽然年龄、性别、AD 基因型和训练状态等因素会影响 TgF344-AD 模型中的焦虑水平，但焦虑水平不会影响记忆表现。 TgF344-AD 大鼠焦虑样行为的增加与记忆力下降无关。 TgF344-AD 大鼠中较高焦虑样行为的预测因子包括年龄、阿尔茨海默病 (AD) 基因型以及与雌性野生型或雄性 AD 相比，雌性 AD 动物经历更大焦虑的性别。 运动训练可减少 TgF344-AD 大鼠的焦虑样行为。