Discovery and in vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening,ChemMedChem

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Discovery and in vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening
ChemMedChem ( IF 3.6 ) Pub Date : 2024-04-15 , DOI: 10.1002/cmdc.202400080
Agata Zięba ₁ , Damian Bartuzi _{1,

2} , Piotr Stępnicki ₁ , Dariusz Matosiuk ₁ , Tomasz M Wróbel ₁ , Tuomo Laitinen ₃ , Marián Castro _{4,

5} , Agnieszka A Kaczor _{1,

3}

Affiliation

Novel serotonin 5-HT_2A receptor ligands were identified in a structure-based virtual screening campaign. These compounds displayed an interesting selectivity profile, including 5-HT_1A, 5-HT_7, and D₂ receptors, characteristic for the second generation of antipsychotics. The reported compounds represent a promising starting point for further optimization campaigns. (Figure generated with BioRender.com)

中文翻译：

通过虚拟筛选鉴定的新型血清素 5-HT2A 受体配体的发现和体外评价

在基于结构的虚拟筛选活动中鉴定出新型血清素 5-HT _2A受体配体。这些化合物表现出有趣的选择性特征，包括 5-HT _1A 、5-HT ₇和 D ₂受体，这是第二代抗精神病药的特征。所报道的化合物为进一步优化活动提供了一个有希望的起点。 （图由 BioRender.com 生成）

更新日期：2024-04-15

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