Figure 1. Nanocarriers compact the nucleic acids, shield them from body fluids, and permit their transport and uptake by target cells (A). Carrier endocytosis can occur spontaneously or be induced by a cellular receptor (B). Subsequently, the nucleic acid must escape the endosome to reach the cytoplasm (C, D). Finally, DNA needs to be protected and delivered to the nucleus (E). Created with BioRender.com. Funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant No. 884505) is acknowledged. This article references 78 other publications. This article has not yet been cited by other publications. Figure 1. Nanocarriers compact the nucleic acids, shield them from body fluids, and permit their transport and uptake by target cells (A). Carrier endocytosis can occur spontaneously or be induced by a cellular receptor (B). Subsequently, the nucleic acid must escape the endosome to reach the cytoplasm (C, D). Finally, DNA needs to be protected and delivered to the nucleus (E). Created with BioRender.com. This article references 78 other publications.

中文翻译：

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生物工程蛋白质作为核酸载体的复兴

图 1. 纳米载体压缩核酸，保护它们免受体液的影响，并允许它们被靶细胞运输和摄取 (A)。载体内吞作用可以自发发生或由细胞受体诱导(B)。随后，核酸必须逃离内体到达细胞质（C，D）。最后，DNA 需要受到保护并输送至细胞核 (E)。使用 BioRender.com 创建。感谢欧洲研究理事会 (ERC) 在欧盟 Horizo​​n 2020 研究和创新计划（拨款号 884505）下提供的资助。本文引用了 78 篇其他出版物。这篇文章尚未被其他出版物引用。图 1. 纳米载体压缩核酸，保护它们免受体液的影响，并允许它们被靶细胞运输和摄取 (A)。载体内吞作用可以自发发生或由细胞受体诱导(B)。随后，核酸必须逃离内体到达细胞质（C，D）。最后，DNA 需要受到保护并输送至细胞核 (E)。使用 BioRender.com 创建。本文引用了 78 篇其他出版物。