We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles using Cu(OTf)₂/HFIP as the excellent promoter system. The reaction proceeds through a one-pot, domino process of spiro cyclization and 1,2-migration followed by aromatization to deliver carbazoles.

中文翻译：

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Cu(OTf)2/HFIP 催化吲哚 C3 功能化炔醇区域选择性环异构化为咔唑

我们在此报道了一种简单且原子经济的吲哚链炔醇环异构化反应，用于使用 Cu(OTf) ₂ /HFIP 作为优异的促进剂系统构建多种咔唑。该反应通过螺环化和 1,2-迁移的一锅多米诺骨牌过程进行，然后芳构化以产生咔唑。