complex (ECCO) comprises closely related Enterobacterales, causing a variety of infections ranging from mild urinary tract infections to severe bloodstream infections. ECCO has emerged as a significant cause of healthcare-associated infections, particularly in neonatal and adult intensive care. The COMplex PASsive Surveillance (EC-COMPASS) aims to provide a detailed multi-centre overview of ECCO epidemiology and resistance patterns detected in routine microbiological diagnostics in four German tertiary-care hospitals. In a sentinel cluster of four German tertiary-care hospitals, all culture-positive ECCO results between 1 January 2020 and 31 December 2022, were analysed based on Hybase® laboratory data. Analysis of 31,193 ECCO datasets from 14,311 patients revealed a higher incidence in male patients (<0.05), although no significant differences were observed in ECCO infection phenotypes. The most common sources of ECCO were swabs (42.7%), urine (17.5%), respiratory secretions (16.1%), blood cultures (8.9%) and tissue samples (5.6%). The annual bacteraemia rate remained steady at approximately 33 cases per hospital. Invasive ECCO infections were predominantly found in oncology and intensive care units. Incidences of nosocomial outbreaks were infrequent and limited in scope. Notably, resistance to carbapenems was consistently low. EC-COMPASS offers a profound clinical perspective on ECCO infections in German tertiary-healthcare settings, highlighting elderly men in oncology and intensive care units as especially vulnerable to ECCO infections. Early detection strategies targeting at-risk patients could improve ECCO infection management.

中文翻译：

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EC-COMPASS：阴沟肠杆菌复合体的长期、多中心监测——临床视角


复合体（ECCO）由密切相关的肠杆菌组成，可引起从轻度尿路感染到严重血流感染的多种感染。 ECCO 已成为医疗保健相关感染的一个重要原因，特别是在新生儿和成人重症监护中。复杂的 PASsive 监测 (EC-COMPASS) 旨在提供 ECCO 流行病学和在四家德国三级医院的常规微生物诊断中检测到的耐药模式的详细多中心概述。在由四家德国三级医院组成的哨点集群中，根据 Hybase® 实验室数据对 2020 年 1 月 1 日至 2022 年 12 月 31 日期间所有培养阳性 ECCO 结果进行了分析。对来自 14,311 名患者的 31,193 个 ECCO 数据集的分析显示，男性患者的发病率较高 (<0.05)，但 ECCO 感染表型没有观察到显着差异。 ECCO最常见的来源是拭子（42.7%）、尿液（17.5%）、呼吸道分泌物（16.1%）、血培养物（8.9%）和组织样本（5.6%）。每家医院的每年菌血症发生率稳定在约 33 例。侵袭性 ECCO 感染主要见于肿瘤科和重症监护病房。医院内爆发的事件并不常见，而且范围有限。值得注意的是，对碳青霉烯类药物的耐药性始终较低。 EC-COMPASS 对德国三级医疗机构中的 ECCO 感染提供了深刻的临床视角，强调肿瘤科和重症监护病房的老年男性特别容易受到 ECCO 感染。针对高危患者的早期检测策略可以改善 ECCO 感染管理。