Background The geroscience hypothesis posits that aging biological processes contribute to many age-related deficits, including the accumulation of multiple chronic diseases. Though only one facet of mitochondrial function, declines in muscle mitochondrial bioenergetic capacities may contribute to this increased susceptibility to multimorbidity. Methods The Study of Muscle, Mobility and Aging (SOMMA) assessed ex vivo muscle mitochondrial energetics in 764 older adults (mean age =76.4, 56.5% women, 85.9% non-Hispanic white) by high-resolution respirometry of permeabilized muscle fibers. We estimated the proportional odds ratio (POR [95%CI]) for the likelihood of greater multimorbidity (four levels: 0 conditions, N=332; 1 condition, N=299; 2 conditions, N=98; or 3+ conditions, N=35) from an index of 11 conditions, per SD decrement in muscle mitochondrial energetic parameters. Distribution of conditions allowed for testing the associations of maximal muscle energetics with some individual conditions. Results Lower oxidative phosphorylation supported by fatty acids and/or complex-I and -II linked carbohydrates (e.g., Max OXPHOSCI+CII) was associated with a greater multimorbidity index score (POR=1.32[1.13,1.54]) and separately with diabetes mellitus (OR=1.62[1.26,2.09]), depressive symptoms (OR=1.45[1.04,2.00]) and possibly chronic kidney disease (OR=1.57[0.98,2.52]) but not significantly with other conditions (e.g., cardiac arrhythmia, chronic obstructive pulmonary disease). Conclusions Lower muscle mitochondrial bioenergetic capacities was associated with a worse composite multimorbidity index score. Our results suggest that decrements in muscle mitochondrial energetics may contribute to a greater global burden of disease and is more strongly related to some conditions than others.

中文翻译：

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肌肉线粒体生物能能力与老年人的多病负担相关：肌肉、活动性和衰老研究 (SOMMA)

背景老年科学假说认为，衰老的生物过程会导致许多与年龄相关的缺陷，包括多种慢性疾病的积累。虽然这只是线粒体功能的一个方面，但肌肉线粒体生物能能力的下降可能会导致对多种疾病的易感性增加。方法 肌肉、活动性和衰老研究 (SOMMA) 通过透化肌纤维的高分辨率呼​​吸测量法评估了 764 名老年人（平均年龄 = 76.4 岁，56.5% 女性，85.9% 非西班牙裔白人）的离体肌肉线粒体能量。我们估计了更大的多重发病可能性的比例比值比 (POR [95%CI])（四个级别：0 种情况，N=332；1 种情况，N=299；2 种情况，N=98；或 3+ 种情况， N=35）来自 11 个条件的索引，肌肉线粒体能量参数每 SD 减少一次。条件分布允许测试最大肌肉能量与某些个体条件的关联。结果由脂肪酸和/或复合物-I 和-II 连接的碳水化合物（例如 Max OXPHOSCI+CII）支持的较低氧化磷酸化与较高的多病指数评分 (POR=1.32[1.13,1.54]) 相关，并且与糖尿病单独相关(OR=1.62[1.26,2.09])、抑郁症状 (OR=1.45[1.04,2.00]) 和可能的慢性肾脏疾病 (OR=1.57[0.98,2.52])，但与其他疾病（例如心律失常、慢性阻塞性肺疾病）。结论 较低的肌肉线粒体生物能能力与较差的综合多病指数评分相关。我们的结果表明，肌肉线粒体能量的减少可能会导致更大的全球疾病负担，并且与某些疾病的相关性比其他疾病的相关性更强。