Fungi infection is a serious threat to public health, but an effective antifungal strategy remains a challenge. Herein, a biomimetic nanocomposite with multifunctionalities, including fungi diagnosis, antifungal adhesion, precise fungi elimination, and cytokine sequestration, is constructed for battling () infection. By screening a range of cells, we find that the polarized macrophage cells have the strongest binding tendency toward . Thus, their membranes were exfoliated to camouflage UCNPs and then decorated with photosensitizers (methylene blue, MB) and DNA sensing elements. The resulting nanocomposite can tightly bind to fungal surfaces, promote DNA recognition, and squeeze pro-inflammatory cytokines to relieve inflammation. Consequently, this nanocomposite can detect with enhanced sensitivity and precisely eliminate fungal cells through photodynamic therapy with minimal phototoxicity because of its switchable fluorescence behavior. The developed nanocomposite with good biocompatibility achieves a satisfactory diagnostic and therapeutic effect in a -infected mouse model, which offers a unique approach to fight fungi infection.

中文翻译：

---

用于精密真菌治疗诊断的仿生和多功能纳米复合材料

真菌感染对公众健康构成严重威胁，但有效的抗真菌策略仍然是一个挑战。在此，构建了一种具有多功能的仿生纳米复合材料，包括真菌诊断、抗真菌粘附、精确消除真菌和细胞因子隔离，用于对抗感染。通过筛选一系列细胞，我们发现极化的巨噬细胞对 的结合倾向最强。因此，它们的膜被剥落以伪装 UCNP，然后用光敏剂（亚甲蓝，MB）和 DNA 传感元件装饰。由此产生的纳米复合材料可以与真菌表面紧密结合，促进DNA识别，并挤压促炎细胞因子以缓解炎症。因此，这种纳米复合材料可以通过光动力疗法以更高的灵敏度进行检测并精确消除真菌细胞，并且由于其可切换的荧光行为而具有最小的光毒性。所开发的具有良好生物相容性的纳米复合材料在感染的小鼠模型中取得了令人满意的诊断和治疗效果，为对抗真菌感染提供了独特的方法。