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Predictors of urinary heavy metal concentrations among pregnant women in Jinan, China
Journal of Trace Elements in Medicine and Biology ( IF 3.5 ) Pub Date : 2024-03-30 , DOI: 10.1016/j.jtemb.2024.127444 Jiayi Song , Xiang Wang , Qichen Huang , Chuanling Wei , Dongxia Yang , Cuilan Wang , Kefeng Fan , Shuang Cheng , Xiaohui Guo , Ju Wang
Journal of Trace Elements in Medicine and Biology ( IF 3.5 ) Pub Date : 2024-03-30 , DOI: 10.1016/j.jtemb.2024.127444 Jiayi Song , Xiang Wang , Qichen Huang , Chuanling Wei , Dongxia Yang , Cuilan Wang , Kefeng Fan , Shuang Cheng , Xiaohui Guo , Ju Wang
Toxic heavy metal exposure and insufficiency or excess of essential heavy metals may have negative effects on pregnant women’s health and fetal growth. To date, the predictors of pregnant women’s heavy metal exposure levels remain unclear and vary with different regions. The study intended to explore potential predictors of exposure to heavy metals individually and high co-exposure to heavy metal mixtures. We recruited 298 pregnant women in first trimester from prenatal clinics in Jinan, Shandong Province, China, and collected spot urine samples and questionnaire data on their demographic characteristics, lifestyle habits, consumption of food and dietary supplement, and residential environment. All urine samples were analyzed for seven heavy metals: cobalt (Co), molybdenum (Mo), strontium (Sr), arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg). Factors associated with single heavy metal concentration were as follows: a) urinary As, Sr and Cd increased with women’s age respectively; b) pregnant women with higher monthly household income per capita had lower Sr and Mo levels; c) pregnant women with intermittent folic acid supplementation and those not taking tap water as domestic drinking water had lower Sr concentrations; d) Cd was positively linked with consumption frequency of rice; e) Hg was adversely related to consumption frequency of egg and the women who took purified water as domestic drinking water had lower Hg exposure. In addition, pregnant women’s age was positively associated with odds of high co-exposure to Co, As, Sr, Mo, Cd and Pb; while those with an educational level of college had lower odds of high exposure to such a metal mixture compared with those whose educational levels were lower than high school. Predictors of single urinary heavy metal concentration included pregnant women’s age (As, Sr and Cd), monthly household income per capita (Sr and Mo), folic acid supplementation (Sr), rice consumption frequency (Cd), egg consumption frequency (Hg) and the type of domestic drinking water (Sr and Hg). Pregnant women with older age, lower educational level tended to have high co-exposure to Co, As, Sr, Mo, Cd and Pb.
更新日期：2024-03-30
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