An improved protocol has been developed for the direct sulfonamidation of unactivated alkyl alcohols using In(OTf)₃ as a Lewis acid catalyst. Although the established methods using Lewis or Brønsted acids have been well-studied for the direct functionalization of alcohols, their substrate scope mainly focuses on the π-activated alcohols. In this reaction, unactivated aliphatic alcohols were evaluated and afforded the desired sulfonamide products with good to excellent yields.

中文翻译：

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铟促进未活化醇的直接磺酰胺化

开发了一种改进的方案，用于使用 In(OTf) ₃作为路易斯酸催化剂对未活化的烷基醇进行直接磺酰胺化。尽管使用路易斯酸或布朗斯台德酸的既定方法已针对醇的直接官能化进行了深入研究，但其底物范围主要集中在 π 活化醇上。在此反应中，对未活化的脂肪醇进行了评估，并以良好至优异的收率提供了所需的磺酰胺产物。