A palladium-catalyzed iodine-assisted carbonylation reaction of indoles with readily available ClCF₂CO₂Na and alcohols has been developed. This protocol provides a practical and efficient approach to highly regioselective indole-3-carboxylates via a preiodination strategy of indoles. Different from classic carbonylation using toxic and difficult-to-handle carbon monoxide, this operationally simple and scalable reaction employed difluorocarbene as the carbonyl surrogate.

中文翻译：

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钯催化碘辅助 ClCF2CO2Na 和醇对吲哚的羰基化反应

已经开发出钯催化的碘辅助吲哚与容易获得的ClCF ₂ CO ₂ Na和醇的羰基化反应。该协议通过吲哚的预碘化策略提供了一种实用且有效的方法来获得高度区域选择性的吲哚-3-羧酸盐。与使用有毒且难以处理的一氧化碳的经典羰基化不同，这种操作简单且可扩展的反应采用二氟卡宾作为羰基替代物。