A copper-catalyzed direct ortho-Csp²–H thiocyanation of free anilines has been developed. This method employs stable and non-toxic ammonium thiocyanate as a thiocyanation source, and tert-butyl hydroperoxide as the oxidant, enabling the synthesis of ortho-thiocyanated anilines with good yields and broad substrate tolerance. Hitherto, no reports have been found in the literature for the ortho-thiocyanation of aromatic amines, making this reaction an important breakthrough in synthetic organic chemistry.

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铜催化芳香胺的邻位硫氰化反应

已开发出铜催化的游离苯胺的直接邻-Csp ² -H硫氰化反应。该方法采用稳定、无毒的硫氰酸铵作为硫氰化源，叔丁基过氧化氢作为氧化剂，合成了收率高、底物耐受性广的邻硫氰化苯胺。迄今为止，尚未见有关芳香胺邻位硫氰化反应的文献报道，该反应成为有机合成化学的重要突破。