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Building an Arduino-Based Open-Source Programmable Multichannel Syringe Pump: A Useful Tool for Fluid Delivery in Microfluidics and Flow Chemistry
Journal of Chemical Education ( IF 3 ) Pub Date : 2024-04-09 , DOI: 10.1021/acs.jchemed.4c00033
Yuting Wu 1 , Yuxin Chen 1 , Yi Cheng 1
Affiliation  

Microfluidics has attracted widespread interest in the fields of chemicals, materials, pharmaceuticals, biology, etc. Integrating low-cost automation based on open-source hardware/software to improve lab security and reduce time consumption is demanded in microchemical processing. In this work, we developed a “do it yourself” multichannel syringe pump by using easily available low-cost components and microcontrollers, which can be used for educational and/or research purposes in the study of microfluidics and flow chemistry. An Arduino UNO board with CNC shield expansion board and A4988 stepper motor driver is used to control the injection volume and rate of the four syringes. The Arduino-based open-source community minimizes the technical knowledge required to build the system and makes it readily shareable. Detailed fabrication guidelines are provided for the device, which is priced well below commercial alternatives and promotes the development of open hardware for microprocess engineering. The operation of the syringe pump can be controlled by the Arduino IDE or other software through the serial port, which is very beneficial for integration with other devices. Moreover, this multichannel syringe pump is also programmable and can be automatically operated. In order to verify the utility of the platform, we have carried out relevant demonstration experiments of microcapsule preparation for functioning cosmetic product and droplet generation based on microfluidic technique. From an educational point of view, students in the lab have the opportunity to learn how to design and build chemistry experimental devices from principles and demands in a hands-on learning environment, preparing them to work in modern and intelligent laboratories.

中文翻译:

构建基于 Arduino 的开源可编程多通道注射泵:微流体和流动化学中流体输送的有用工具

微流控已引起化学、材料、制药、生物等领域的广泛关注。微化学处理需要集成基于开源硬件/软件的低成本自动化,以提高实验室安全性并减少时间消耗。在这项工作中,我们通过使用易于获得的低成本组件和微控制器开发了一种“自己动手”的多通道注射泵,可用于微流体和流动化学研究中的教育和/或研究目的。带有 CNC 扩展板和 A4988 步进电机驱动器的 Arduino UNO 板用于控制四个注射器的注射量和速率。基于 Arduino 的开源社区最大限度地减少了构建系统所需的技术知识,并使其易于共享。该器件提供了详细的制造指南,其价格远低于商业替代品,并促进了微处理工程开放硬件的开发。注射泵的运行可以通过串口由Arduino IDE或其他软件控制,这非常有利于与其他设备的集成。此外,这种多通道注射泵也是可编程的并且可以自动操作。为了验证该平台的实用性,我们开展了功能性化妆品微胶囊制备以及基于微流控技术的液滴生成的相关演示实验。从教育的角度来看,实验室的学生有机会在动手学习的环境中,从原理和需求出发,学习如何设计和搭建化学实验装置,为他们在现代化、智能化实验室中工作做好准备。
更新日期:2024-04-10
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