Background Migraine is common in women of reproductive age. This study aimed to (1) describe the prevalence of migraine in pregnant women in the UK, (2) identify drugs commonly prescribed for migraine during pregnancy and (3) identify characteristics associated with being prescribed medication for migraine during pregnancy. Methods The Clinical Practice Research Datalink pregnancy register, a database of pregnancy episodes identified in anonymised primary care health records, was used. Crude and age-standardised prevalence of migraine during pregnancy and the proportion of women with migraine prescribed drugs used for migraine management were calculated for each year between 2000 and 2018. Logistic regression was used to describe the relationship between patient characteristics and being prescribed migraine medication during pregnancy. Results 1 377 053 pregnancies were included, of which 187 328 were in women with a history of migraine. The age-adjusted prevalence increased from 11.4% in 2000 to 17.2% in 2018. There was an increase in the rates of prescription for numerous medications for the management of migraine. Older women (adjusted OR (aOR) 1.41 (1.20 to 1.66)), women of black (aOR 1.40 (1.32 to 1.48)) and South Asian ethnicity (aOR 1.48 (1.38 to 1.59)), those living in the most deprived areas (aOR 1.60 (1.54 to 1.66)), women who were obese (aOR 1.39 (1.35 to 1.43)), smokers (aOR 1.15 (1.12 to 1.18)) and those with comorbid conditions were more likely to receive a prescription during pregnancy. Conclusions Rates of recorded migraine have increased over the past two decades as well as rates of prescribing in women with migraine. Higher prescribing rates are seen in certain groups, which has the potential to exacerbate health inequalities. Data may be obtained from a third party and are not publicly available. The data that support the findings of this study are available from CPRD but restrictions apply to the availability of these data, which were used under licence for the current study, and so are not publicly available.

中文翻译：

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2000-2018 年英国妊娠期间偏头痛的患病率和药物治疗趋势

背景 偏头痛在育龄妇女中很常见。本研究旨在 (1) 描述英国孕妇偏头痛的患病率，(2) 确定怀孕期间常用治疗偏头痛的药物，以及 (3) 确定与怀孕期间服用偏头痛药物相关的特征。方法 使用临床实践研究数据链妊娠登记册，这是匿名初级保健健康记录中确定的妊娠事件数据库。计算了 2000 年至 2018 年间每年的粗略年龄标准化偏头痛患病率以及患有偏头痛的女性使用偏头痛处方药物的比例。使用逻辑回归来描述患者特征与怀孕期间偏头痛处方药物之间的关系。怀孕。结果 纳入 1 377 053 例妊娠，其中 187 328 例为有偏头痛病史的女性。年龄调整后的患病率从 2000 年的 11.4% 上升至 2018 年的 17.2%。用于治疗偏头痛的多种药物的处方率有所增加。老年妇女（调整后的 OR (aOR) 1.41（1.20 至 1.66））、黑人妇女（aOR 1.40（1.32 至 1.48））和南亚裔妇女（aOR 1.48（1.38 至 1.59））、生活在最贫困地区的妇女（ aOR 1.60（1.54 至 1.66））、肥胖女性（aOR 1.39（1.35 至 1.43））、吸烟者（aOR 1.15（1.12 至 1.18））以及患有合并症的女性更有可能在怀孕期间接受处方治疗。结论 在过去二十年中，记录的偏头痛发生率有所增加，偏头痛女性的处方率也有所增加。某些群体的处方率较高，这有可能加剧健康不平等。数据可能从第三方获得，并且不公开。支持本研究结果的数据可从 CPRD 获得，但这些数据的可用性受到限制，这些数据是在当前研究的许可下使用的，因此不公开。