Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology,Alzheimer's & Dementia

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Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2024-04-04 , DOI: 10.1002/alz.13791
Kristiana Xhima ₁ , Julie Ottoy ₁ , Erin Gibson ₁ , Katherine Zukotynski _{1,

2,

3} , Christopher Scott ₁ , Ginelle J. Feliciano ₁ , Sabrina Adamo ₁ , Phillip H. Kuo ₄ , Michael J. Borrie ₅ , Howard Chertkow ₆ , Richard Frayne ₇ , Robert Laforce ₈ , Michael D. Noseworthy _{2,

9} , Frank S. Prato ₅ , Demetrios J. Sahlas ₁₀ , Eric E. Smith ₁₁ , Vesna Sossi ₁₂ , Alexander Thiel ₁₃ , Jean‐Paul Soucy ₁₄ , Jean‐Claude Tardif ₁₅ , Maged Goubran _{1,

16,

17} , Sandra E. Black _{1,

18} , Joel Ramirez ₁ ,

Affiliation

Dr. Sandra E. Black Centre for Brain Resilience and Recovery LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto Toronto Ontario Canada
Departments of Medicine and Radiology McMaster University Hamilton Ontario Canada
Department of Medical Imaging Schulich School of Medicine and Dentistry, Western University London Ontario Canada
Departments of Medical Imaging, Medicine, Biomedical Engineering University of Arizona Tucson Arizona USA
Schulich School of Medicine and Dentistry Western University London Ontario Canada
Rotman Research Institute Baycrest Health Sciences Toronto Ontario Canada
Departments of Radiology and Clinical Neuroscience Hotchkiss Brain Institute, University of Calgary Calgary Alberta Canada
Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques Université Laval, Quebec City Quebec Canada
Department of Electrical and Computer Engineering McMaster University Hamilton Ontario Canada
Department of Medicine McMaster University Hamilton Ontario Canada
Department of Clinical Neurosciences and Hotchkiss Brain Institute University of Calgary Calgary Alberta Canada
Physics and Astronomy Department and DM Center for Brain Health University of British Columbia Vancouver British Columbia Canada
Department of Neurology and Neurosurgery McGill University Montreal Quebec Canada
Montreal Neurological Institute McGill University Montreal Quebec Canada
Montreal Heart Institute Université de Montréal Montreal Quebec Canada
Department of Medical Biophysics University of Toronto Toronto Ontario Canada
Physical Sciences Platform, Sunnybrook Research Institute University of Toronto Toronto Ontario Canada
Division of Neurology Department of Medicine University of Toronto Toronto Ontario Canada

Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co-exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood.

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