Intracerebral hemorrhage (ICH) represents one of the most severe subtypes of stroke. Due to the complexity of the brain injury mechanisms following ICH, there are currently no effective treatments to significantly improve patient functional outcomes. Curcumin, as a potential therapeutic agent for ICH, is limited by its poor water solubility and oral bioavailability. In this study, mPEG‐PCL is used to encapsulate curcumin, forming curcumin nanoparticles, and utilized the intranasal administration route to directly deliver curcumin nanoparticles from the nasal cavity to the brain. By inhibiting pro‐inflammatory neuroinflammation of microglia following ICH in mice, reprogramming pro‐inflammatory microglia toward an anti‐inflammatory function, and consequently reducing neuronal inflammatory death and hematoma volume, this approach improved blood‐brain barrier damage in ICH mice and promoted the recovery of neurological function post‐stroke. This study offers a promising therapeutic strategy for ICH to mediate neuroinflammatory microenvironments.

中文翻译：

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鼻内递送姜黄素纳米颗粒可改善脑出血小鼠的神经炎症和神经功能缺损

脑出血（ICH）是最严重的中风亚型之一。由于ICH后脑损伤机制的复杂性，目前尚无有效的治疗方法可以显着改善患者的功能结果。姜黄素作为脑出血的潜在治疗剂，因其水溶性差和口服生物利用度而受到限制。本研究采用mPEG-PCL封装姜黄素，形成姜黄素纳米颗粒，并利用鼻内给药途径将姜黄素纳米颗粒从鼻腔直接递送至大脑。通过抑制小鼠ICH后小胶质细胞的促炎性神经炎症，将促炎性小胶质细胞重新编程为抗炎功能，从而减少神经元炎症死亡和血肿体积，该方法改善了ICH小鼠的血脑屏障损伤并促进了恢复中风后的神经功能。这项研究为 ICH 介导神经炎症微环境提供了一种有前景的治疗策略。