Evidence suggests that exposure to per- and polyfluoroalkyl substances (PFAS) increases risk of high blood pressure (BP) during pregnancy. Prior studies did not examine associations with BP trajectory parameters (i.e., overall magnitude and velocity) during pregnancy, which is linked to adverse pregnancy outcomes. To estimate associations of multiple plasma PFAS in early pregnancy with BP trajectory parameters across the second and third trimesters. To assess potential effect modification by maternal age and parity. In 1297 individuals, we quantified six PFAS in plasma collected during early pregnancy (median gestational age: 9.4 weeks). We abstracted from medical records systolic BP (SBP) and diastolic BP (DBP) measurements, recorded from 12 weeks gestation until delivery. BP trajectory parameters were estimated via Super Imposition by Translation and Rotation modeling. Subsequently, Bayesian Kernel Machine Regression (BKMR) was employed to estimate individual and joint associations of PFAS concentrations with trajectory parameters – adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index, income, parity, smoking status, and seafood intake. We evaluated effect modification by age at enrollment and parity. We collected a median of 13 BP measurements per participant. In BKMR, higher concentration of perfluorooctane sulfonate (PFOS) was independently associated with higher magnitude of overall SBP and DBP trajectories (i.e., upward shift of trajectories) and faster SBP trajectory velocity, holding all other PFAS at their medians. In stratified BKMR analyses, participants with ≥ 1 live birth had more pronounced positive associations between PFOS and SBP velocity, DBP magnitude, and DBP velocity – compared to nulliparous participants. We did not observe significant associations between concentrations of the overall PFAS mixture and either magnitude or velocity of the BP trajectories. Early pregnancy plasma PFOS concentrations were associated with altered BP trajectory in pregnancy, which may impact future cardiovascular health of the mother.

中文翻译：

---

妊娠早期血浆 PER- 和多氟烷基物质 (PFAS) 以及妊娠中期和晚期的血压轨迹

有证据表明，接触全氟烷基物质和多氟烷基物质 (PFAS) 会增加怀孕期间患高血压 (BP) 的风险。先前的研究没有检查怀孕期间与血压轨迹参数（即总体幅度和速度）的关联，这与不良妊娠结局有关。评估妊娠早期多种血浆 PFAS 与妊娠中期和晚期血压轨迹参数的关联。评估母亲年龄和胎次的潜在影响。我们对 1297 名个体在妊娠早期（中位孕龄：9.4 周）期间收集的血浆中的 6 种 PFAS 进行了定量。我们从医疗记录中提取了从妊娠 12 周直至分娩期间记录的收缩压 (SBP) 和舒张压 (DBP) 测量值。 BP 轨迹参数通过平移和旋转建模的超级拼版进行估计。随后，采用贝叶斯核机器回归 (BKMR) 来估计 PFAS 浓度与轨迹参数的个体和联合关联 - 调整孕妇年龄、种族/民族、孕前体重指数、收入、胎次、吸烟状况和海鲜摄入量。我们根据入组年龄和胎次评估了效应修正。我们收集了每位参与者平均 13 次血压测量值。在 BKMR 中，较高浓度的全氟辛烷磺酸 (PFOS) 与整体 SBP 和 DBP 轨迹的较高幅度（即轨迹向上移动）和较快的 SBP 轨迹速度独立相关，使所有其他 PFAS 保持在中值。在分层 BKMR 分析中，与未生育的参与者相比，活产数≥1 的参与者的 PFOS 与收缩压速度、舒张压幅度和舒张压速度之间存在更显着的正相关性。我们没有观察到整个 PFAS 混合物的浓度与 BP 轨迹的大小或速度之间存在显着关联。怀孕早期血浆 PFOS 浓度与怀孕期间血压轨迹的改变有关，这可能会影响母亲未来的心血管健康。