Buprenorphine is commonly used as a treatment for opioid use disorder (OUD). Transition to buprenorphine traditionally has been done using a low-dose initiation regimen due to concerns surrounding precipitated withdrawal. There are increasing data supporting use of a high-dose initiation regimen in the nonpregnant population. This retrospective case series describes six individuals with OUD who underwent high-dose buprenorphine initiation in pregnancy. There were no instances of sedation, respiratory depression, supplemental oxygen use, or death. All individuals were successfully transitioned to buprenorphine. These findings provide support for high-dose buprenorphine initiation in pregnancy, but future large studies are needed.

中文翻译：

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高剂量丁丙诺啡起始治疗妊娠期阿片类药物使用障碍。

丁丙诺啡通常用于治疗阿片类药物使用障碍 (OUD)。由于担心突然停药，传统上使用低剂量起始方案过渡到丁丙诺啡。越来越多的数据支持在非妊娠人群中使用高剂量起始方案。本回顾性病例系列描述了 6 名 OUD 患者，他们在怀孕期间接受了高剂量丁丙诺啡治疗。没有出现镇静、呼吸抑制、补充氧气使用或死亡的情况。所有个体均成功过渡到丁丙诺啡。这些发现为怀孕期间开始使用高剂量丁丙诺啡提供了支持，但还需要未来的大型研究。