Background

The extent of left ventricular (LV) trabeculation and its relationship with cardiovascular (CV) risk factors is unclear.

Purpose

To apply automated segmentation to UK Biobank cardiac MRI scans to (a) assess the association between individual characteristics and CV risk factors and trabeculated LV mass (LVM) and (b) establish normal reference ranges in a selected group of healthy UK Biobank participants.

Materials and Methods

In this cross-sectional secondary analysis, prospectively collected data from the UK Biobank (2006 to 2010) were retrospectively analyzed. Automated segmentation of trabeculations was performed using a deep learning algorithm. After excluding individuals with known CV diseases, White adults without CV risk factors (reference group) and those with preexisting CV risk factors (hypertension, hyperlipidemia, diabetes mellitus, or smoking) (exposed group) were compared. Multivariable regression models, adjusted for potential confounders (age, sex, and height), were fitted to evaluate the associations between individual characteristics and CV risk factors and trabeculated LVM.

Results

Of 43 038 participants (mean age, 64 years ± 8 [SD]; 22 360 women), 28 672 individuals (mean age, 66 years ± 7; 14 918 men) were included in the exposed group, and 7384 individuals (mean age, 60 years ± 7; 4729 women) were included in the reference group. Higher body mass index (BMI) (β = 0.66 [95% CI: 0.63, 0.68]; P < .001), hypertension (β = 0.42 [95% CI: 0.36, 0.48]; P < .001), and higher physical activity level (β = 0.15 [95% CI: 0.12, 0.17]; P < .001) were associated with higher trabeculated LVM. In the reference group, the median trabeculated LVM was 6.3 g (IQR, 4.7–8.5 g) for men and 4.6 g (IQR, 3.4–6.0 g) for women. Median trabeculated LVM decreased with age for men from 6.5 g (IQR, 4.8–8.7 g) at age 45–50 years to 5.9 g (IQR, 4.3–7.8 g) at age 71–80 years (P = .03).

Conclusion

Higher trabeculated LVM was observed with hypertension, higher BMI, and higher physical activity level. Age- and sex-specific reference ranges of trabeculated LVM in a healthy middle-aged White population were established.

© RSNA, 2024

Supplemental material is available for this article.

See also the editorial by Kawel-Boehm in this issue.

中文翻译：

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心脏 MRI 的左心室小梁：英国生物银行中的参考范围及其与心血管危险因素的关联

背景

左心室（LV）小梁形成的范围及其与心血管（CV）危险因素的关系尚不清楚。

目的

将自动分割应用于 UK Biobank 心脏 MRI 扫描，以 ( a ) 评估个体特征与 CV 风险因素和小梁化 LV 质量 (LVM) 之间的关联，以及 ( b ) 在选定的一组健康 UK Biobank 参与者中建立正常参考范围。

材料和方法

在这项横断面二次分析中，对从英国生物银行（2006 年至 2010 年）前瞻性收集的数据进行了回顾性分析。使用深度学习算法进行小梁的自动分割。在排除患有已知心血管疾病的个体后，对没有心血管危险因素（参考组）和已有心血管危险因素（高血压、高脂血症、糖尿病或吸烟）的白人成年人（暴露组）进行比较。针对潜在混杂因素（年龄、性别和身高）进行调整的多变量回归模型被拟合，以评估个体特征与心血管危险因素和小梁化 LVM 之间的关联。

结果

在 43 038 名参与者（平均年龄 64 岁 ± 8 [SD]；22 360 名女性）中，暴露组包括 28 672 名个体（平均年龄 66 岁 ± 7 岁；14 918 名男性），7 384 名个体（平均年龄） ，60 岁±7；4729 名女性）被纳入参考组。较高的体重指数 (BMI)（β = 0.66 [95% CI: 0.63, 0.68]；P < .001）、高血压（β = 0.42 [95% CI: 0.36, 0.48]；P < .001）及更高体力活动水平 (β = 0.15 [95% CI: 0.12, 0.17]; P < .001) 与较高的小梁 LVM 相关。在参考组中，男性中位小梁 LVM 为 6.3 克（IQR，4.7-8.5 克），女性为 4.6 克（IQR，3.4-6.0 克）。男性中位小梁 LVM 随着年龄的增长而下降，从 45-50 岁时的 6.5 克（IQR，4.8-8.7 克）降至 71-80 岁时的 5.9 克（IQR，4.3-7.8 克）（P = .03）。

结论

观察到较高的小梁 LVM 与高血压、较高的 BMI 和较高的体力活动水平有关。建立了健康中年白人群体中年龄和性别特定的小梁 LVM 参考范围。

© 北美放射学会，2024

本文提供了补充材料。

另请参阅本期 Kawel-Boehm 的社论。