BackgroundThe relationship between epinephrine and cancer can be dose‐dependent in in vivo study. Whether it is the same in human body still needs verification.MethodWe used frozen human pancreatic ductal adenocarcinoma (PDAC) tissues to detect epinephrine content and analyzed its relationship with survival using the K‐M method and Cox regression. Disturbance of blood cell count and C‐reactive protein and identification of related potent intermediary factors were also analyzed.ResultsK‐M plot and Cox regression all showed the inverted U‐shaped relationship between epinephrine and PDAC survival. Lymphocyte adjustment can increase the HRs of epinephrine for PDAC death by >10%.ConclusionEpinephrine played an anti‐tumor or pro‐tumor effect depending on the specific concentration. Circulating lymphocyte count was elevated and might acted as a compensation pathway to reduce the pro‐tumor effect of epinephrine to PDAC.

中文翻译：

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淋巴细胞代偿性肾上腺素与胰腺导管腺癌患者生存的倒U型关系

背景在体内研究中，肾上腺素与癌症之间的关系可能呈剂量依赖性。人体内是否相同尚需验证。方法采用冷冻人胰腺导管腺癌（PDAC）组织检测肾上腺素含量，并采用K-M法和Cox回归分析其与生存的关系。还分析了血细胞计数和C反应蛋白的干扰以及相关有效中间因素的鉴定。结果K-M图和Cox回归均显示肾上腺素与PDAC存活之间的倒U形关系。淋巴细胞调节可使肾上腺素导致PDAC死亡的HRs增加>10%。结论肾上腺素根据具体浓度发挥抗肿瘤或促肿瘤作用。循环淋巴细胞计数升高，可能作为一种补偿途径，减少肾上腺素对 PDAC 的促肿瘤作用。