High glucose blood and bacterial infection remain major issues for the slow healing of diabetic wounds, so developing functional biosensing composite with excellent antibacterial and remarkable glucose response sensitivity is necessary and prospective. Herein, by in situ synthesis AgNPs on the surface of self-prepared PTIGA elastomers, PTIGA-AgNPs conductive composites are obtained with efficient synergistic antibacterial effect, excellent mechanical and self-healing properties. The strain of the composites can reach 1800%, and its self-healing efficiency exceeds 90% at 60 °C within 8 h. Both elastomers and composites represent excellent biocompatibility and the antibacterial rate against E. coli and S. aureus exceeded 90%. Moreover, the biosensor assembled from the conductive composites exhibits excellent glucose response sensitivity and stability, with a sensitivity coefficient of 0.518 mA mm⁻¹ in the range of 0.2–3.6 × 10⁻³ m glucose concentration, as well as a low detection limit of 0.08 × 10⁻³ m. Furthermore, based on the remarkable antibacterial performance and bioactivity derived from GA, the composites reduce the expression of pro-inflammatory factors and promote the production of anti-inflammatory factors, and effectively promote the regeneration of skin and granulation tissue of wounds in a diabetic full-thickness skin defect model, demonstrating the enormous therapeutic potential in diabetic wound healing.

中文翻译：

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用于敏感血糖监测和协同伤口愈合的协同抗菌甘草酸基功能生物传感复合材料

高血糖和细菌感染仍然是糖尿病伤口愈合缓慢的主要问题，因此开发具有优异抗菌性和显着葡萄糖反应敏感性的功能性生物传感复合材料是必要且具有前景的。本文通过在自制PTIGA弹性体表面原位合成AgNPs，获得了PTIGA-AgNPs导电复合材料，该复合材料具有高效的协同抗菌作用、优异的机械性能和自修复性能。复合材料的应变可达1800%，60℃下8h内自修复效率超过90%。弹性体和复合材料都具有优异的生物相容性，对大肠杆菌和金黄色葡萄球菌的抗菌率超过90%。此外，由导电复合材料组装而成的生物传感器表现出优异的葡萄糖响应灵敏度和稳定性，在0.2~3.6 × 10 ^-3 m葡萄糖浓度范围内灵敏度系数为0.518 mA m m ^-1，并且检测限较低0.08 × 10 ^-3 m。此外，基于GA的显着抗菌性能和生物活性，该复合材料可减少促炎因子的表达并促进抗炎因子的产生，有效促进糖尿病患者皮肤和伤口肉芽组织的再生。 -厚层皮肤缺损模型，展示了糖尿病伤口愈合的巨大治疗潜力。