Osteoarthritis (OA) is a progressive and degenerative disease associated with articular cartilage injury. Current conservative or surgical treatments cannot effectively terminate the progress of OA, usually leading to total joint replacement at the end stage. Also, it is still challenging to treat cartilage defect for it demands a dual-pronged approach which simultaneously addresses both cartilage repair and the relief of osteochondral inflammation. In this study, we embarked on a pioneering exploration of D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS), an FDA-approved, water-soluble derivative of natural vitamin E. TPGS was found to effectively relieve inflammation both and . We further extended the application of TPGS by establishing an injectable collagen-chondroitin sulfate (CS) hydrogel incorporated with TPGS (TPGS@CS-hydrogel), and achieved excellent cartilage repair. RNA-seq showed that the anti-inflammatory effect of TPGS@CS-hydrogel were related to the interruption of interplay of oxidative stress and inflammation, thus promoting cartilage regeneration. In conclusion, both TPGS and TPGS@CS-hydrogel provided new insights for the prevention and treatment of articular inflammation and cartilage lesion.

中文翻译：

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一种含有 TPGS 的可注射 CS-水凝胶，用于软骨修复

骨关节炎（OA）是一种与关节软骨损伤相关的进行性退行性疾病。目前的保守或手术治疗无法有效终止骨关节炎的进展，通常导致终末期进行全关节置换。此外，治疗软骨缺损仍然具有挑战性，因为它需要双管齐下的方法，同时解决软骨修复和缓解骨软骨炎症的问题。在这项研究中，我们对 D-α-生育酚聚乙二醇 1000 琥珀酸酯 (TPGS) 进行了开创性的探索，这是一种经 FDA 批准的天然维生素 E 的水溶性衍生物。发现 TPGS 可以有效缓解炎症和炎症。我们进一步扩展了TPGS的应用，建立了掺有TPGS的可注射胶原-硫酸软骨素（CS）水凝胶（TPGS@CS-水凝胶），并实现了优异的软骨修复。 RNA-seq表明TPGS@CS-水凝胶的抗炎作用与阻断氧化应激和炎症的相互作用有关，从而促进软骨再生。总之，TPGS和TPGS@CS-水凝胶都为关节炎症和软骨病变的预防和治疗提供了新的见解。