A brand-new procedure for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones has been disclosed via a HOTf or Fe(OTf)₃-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes. Aryl, alkenyl and alkyl terminal alkynes are suitable to couple with a broad range of 3-hydroxyisoindolinones to afford the desired products in moderate to good yields. This protocol features the use of an inexpensive catalyst, mild reaction conditions, broad substrate scope and easy elaboration of the products.

中文翻译：

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3-羟基异吲哚啉酮与末端炔烃的脱水炔基化用于合成 3-炔基化 3,3-二取代异吲哚啉酮

已经公开了通过HOTf或Fe(OTf) 3 催化的_3-羟基异吲哚啉酮与末端炔的脱水炔基化来合成3-炔基化3,3-二取代异吲哚啉酮的全新程序。芳基、烯基和烷基末端炔烃适合与多种 3-羟基异二氢吲哚酮偶联，以中等至良好的收率提供所需的产物。该方案的特点是使用廉价的催化剂、温和的反应条件、广泛的底物范围和易于加工的产品。