ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression,Autophagy

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ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression
Autophagy ( IF 13.3 ) Pub Date : 2024-04-02 , DOI: 10.1080/15548627.2024.2338577
Rossella Benedetti ₁ , Maria Anele Romeo ₁ , Andrea Arena ₁ , Maria Saveria Gilardini Montani ₁ , Gabriella D’Orazi ₂ , Mara Cirone ₁

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The inhibition of the unfolded protein response (UPR), which usually protects cancer cells from stress, may be exploited to potentiate the cytotoxic effect of drugs inducing ER stress. However, in ...

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