Burns can cause severe damage to the skin due to bacterial infection and severe inflammation. Although conductive hydrogels as electroactive burn-wound dressings achieve remarkable effects on accelerating wound healing, issues such as imbalance between their high conductivity and mechanical properties, easy dehydration, and low transparency must be addressed. Herein, a double-network conductive eutectogel is fabricated by integrating polymerizable deep eutectic solvents (PDESs)including acrylamide/choline chloride/glycerol (acrylamide-polymerization crosslink) and thiolated hyaluronic acid (disulfide-bonding crosslink). The introduction of PDESs provides the eutectogel with a conductivity (up to 0.25 S·m⁻¹) and mechanical strength (tensile strain of 59–77%) simulating those of natural human skin, as well as satisfactory tissue adhesiveness, self-healing ability, and antibacterial properties. When combined with exogenous electrical stimulation, the conductive eutectogel exhibits the ability to reduce inflammation, stimulate cell proliferation and migration, promote collagen deposition and angiogenesis, and facilitate skin tissue remodeling. This conductive eutectogel shows great potential as a dressing for healing major burn wounds.

中文翻译：

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导电透明质酸/低共熔溶剂复合水凝胶作为伤口敷料促进电刺激下皮肤烧伤愈合

烧伤会因细菌感染和严重炎症而对皮肤造成严重损害。尽管导电水凝胶作为电活性烧伤创面敷料在加速伤口愈合方面取得了显着效果，但仍需解决其高电导率与机械性能不平衡、易脱水和透明度低等问题。在此，通过整合可聚合的低共熔溶剂（PDES），包括丙烯酰胺/氯化胆碱/甘油（丙烯酰胺聚合交联）和硫醇化透明质酸（二硫键交联），制备了双网络导电共晶凝胶。 PDESs的引入使共熔凝胶具有模拟天然人体皮肤的电导率（高达0.25 S·m ^-1）和机械强度（拉伸应变59%~77%），以及令人满意的组织粘附性、自修复能力和抗菌特性。当与外源性电刺激相结合时，导电共熔凝胶表现出减少炎症、刺激细胞增殖和迁移、促进胶原蛋白沉积和血管生成以及促进皮肤组织重塑的能力。这种导电共熔凝胶显示出作为治疗严重烧伤创面的敷料的巨大潜力。