Conventional cancer therapies typically aim to eliminate tumor cells by inducing cell death. The emergence of resistance to these standard treatments has spurred a shift in focus toward exploring alternative cell death pathways beyond apoptosis. Ferroptosis—an iron-dependent regulated cell death triggered by lipid peroxide accumulation—has gained prominence in cancer research in recent years. Ferroptosis-inducing therapies hold promise for overcoming resistance encountered with conventional treatments. However, challenges, including the lack of distinctive ferroptosis markers and the intricate role of ferroptosis within the tumor microenvironment, currently hinder the clinical translation of these therapies. This perspective article critically outlines these hurdles and highlights unexplored opportunities in ferroptosis research, aiming to refine its therapeutic utilization in combating cancer.

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探索用于癌症治疗的铁死亡诱导疗法：挑战和机遇

传统的癌症疗法通常旨在通过诱导细胞死亡来消除肿瘤细胞。对这些标准治疗的耐药性的出现促使人们将焦点转向探索细胞凋亡以外的替代细胞死亡途径。铁死亡——一种由脂质过氧化物积累引发的铁依赖性调节细胞死亡——近年来在癌症研究中受到重视。铁死亡诱导疗法有望克服传统疗法遇到的耐药性。然而，挑战，包括缺乏独特的铁死亡标志物以及铁死亡在肿瘤微环境中的复杂作用，目前阻碍了这些疗法的临床转化。这篇观点文章批判性地概述了这些障碍，并强调了铁死亡研究中尚未探索的机会，旨在完善其在对抗癌症方面的治疗应用。