INTRODUCTIONThere is limited knowledge about early‐onset dementia (EOD) on fracture risk.METHODSIndividuals ages 50 to 64 were identified from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (2012 to 2019). The association between EOD and fractures and the association between cholinesterase inhibitors for EOD and fractures were evaluated using logistic regression analyses.RESULTSWe identified 13,614 EOD patients and 9,144,560 cognitively healthy individuals. The analysis revealed that EOD was associated with an increased risk of hip fractures (adjusted odds ratio, 95% confidence interval: 8.79, 7.37–10.48), vertebral fractures (1.73, 1.48–2.01), and major osteoporotic fractures (2.05, 1.83–2.30) over 3 years. The use of cholinesterase inhibitors was significantly associated with a reduction in hip fractures among EOD patients (0.28, 0.11–0.69).DISCUSSIONEOD patients have a higher risk of osteoporotic fractures than cognitively healthy individuals. The use of cholinesterase inhibitors may reduce the risk of hip fracture among EOD patients.Highlights It is unknown whether early‐onset dementia (EOD) increases the risk of fractures. We identified 13,614 individuals with EOD using a nationwide administrative database. Patients with EOD have a higher risk of hip, vertebral, and major osteoporotic fractures. The use of cholinesterase inhibitors may reduce hip fracture among patients with EOD.

中文翻译：

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早发性痴呆以及髋部骨折和严重骨质疏松性骨折的风险

简介 关于早发性痴呆 (EOD) 与骨折风险的关系的知识有限。方法从日本国家健康保险索赔和特定健康检查数据库（2012 年至 2019 年）中确定了 50 岁至 64 岁的个人。使用逻辑回归分析评估 EOD 与骨折之间的关联以及 EOD 胆碱酯酶抑制剂与骨折之间的关联。 结果我们确定了 13,614 名 EOD 患者和 9,144,560 名认知健康的个体。分析显示，EOD 与髋部骨折（调整后比值比，95% 置信区间：8.79、7.37–10.48）、椎骨骨折（1.73、1.48–2.01）和严重骨质疏松性骨折（2.05、1.83– 2.30）超过3年。胆碱酯酶抑制剂的使用与 EOD 患者髋部骨折的减少显着相关（0.28，0.11-0.69）。讨论 OD 患者比认知健康的个体发生骨质疏松性骨折的风险更高。使用胆碱酯酶抑制剂可以降低 EOD 患者髋部骨折的风险。亮点 目前尚不清楚早发性痴呆（EOD）是否会增加骨折的风险。 我们利用全国行政数据库确定了 13,614 名 EOD 患者。 EOD 患者发生髋部、椎骨和严重骨质疏松性骨折的风险较高。 使用胆碱酯酶抑制剂可以减少 EOD 患者的髋部骨折。