Current approaches to treating infected pressure ulcers (IPUs) tend to lack specificity. Such injuries frequently exhibit extended inflammation and slow tissue regeneration, largely due to a surplus of M1 macrophages in the impacted regions. While immunomodulatory hydrogels offer potential for targeted IPU care, facilitating a safe and efficient shift from M1 to M2 macrophages continues to be a considerable challenge. The wound's harsh microenvironment—marked by unchecked infections and reactive oxygen species—often undermines the effectiveness of these hydrogels. We unveil a custom-engineered hydrogel dressing specifically designed to have immunomodulatory properties for expediting the healing of IPUs. Consisting of intertwined polymer networks, this hydrogel incorporates gallium (Ga) ions-triggered self-assembled glycyrrhizic acid (GA). Crucially, both and examinations, along with RNA sequencing assessments, demonstrate that the Ga/GA combination successfully reduces the M1/M2 macrophage ratio under inflamed circumstances, thereby contributing to improved IPU wound recovery. In summary, our proposed immunomodulatory strategy provides a simple, secure, and highly efficacious method for managing IPUs.

中文翻译：

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免疫调节镓/甘草酸水凝胶用于治疗多重耐药铜绿假单胞菌感染的压疮

目前治疗感染性压疮 (IPU) 的方法往往缺乏特异性。此类损伤经常表现出持续的炎症和缓慢的组织再生，这主要是由于受影响区域的 M1 巨噬细胞过剩。虽然免疫调节水凝胶为靶向 IPU 护理提供了潜力，但促进从 M1 巨噬细胞安全有效地转变为 M2 巨噬细胞仍然是一个相当大的挑战。伤口恶劣的微环境——以不受控制的感染和活性氧为特征——常常会破坏这些水凝胶的有效性。我们推出了一种定制设计的水凝胶敷料，专门设计具有免疫调节特性，可加速 IPU 的愈合。这种水凝胶由交织的聚合物网络组成，包含镓 (Ga) 离子触发的自组装甘草酸 (GA)。至关重要的是，这两项检查以及 RNA 测序评估都表明，Ga/GA 组合成功降低了发炎情况下的 M1/M2 巨噬细胞比率，从而有助于改善 IPU 伤口恢复。总之，我们提出的免疫调节策略为管理 IPU 提供了一种简单、安全且高效的方法。