Fibrous materials with inherent antimicrobial properties can help in real-time deactivation of microorganisms, enabling multiple uses while reducing secondary infections. Coatings with antiviral polymers enhance the surface functionality for existing and potential future pandemics. Herein, we demonstrated a straightforward route toward biocidal surface creation using polymers with nucleophilic biguanide, guanidine, and hydantoin groups that are covalently attached onto a solid support. Biocidal poly(N-vinylguanidine) (PVG) and poly(allylamine-co-4-aminopyridine-co-5-(4-hydroxybenzylidene)hydantoin) (PAH) were introduced for coating applications along with commercially available polyvinylamine (PVAm) and poly(hexamethylene biguanide) (PHMB). Nonleaching coatings were created by first fabricating bifunctional siloxane or isocyanate precursor coatings on the cotton, nylon–cotton, and glass fiber fabric, followed by the polymer attachment. The developed grafting methods ensured the stability of the coating and the reuse of the material while maintaining the biocidal properties. Halogenation of polymer-coated fabric was conducted by aqueous solutions of sodium hypochlorite or in situ generation of hypobromous acid (HOBr), resulting in surfaces coated by N-halamines with high contents of active > N–Cl or > N–Br groups. The polymer-coated fabrics were stable in multiple laundry cycles and maintained hydrophilic character after coating and halogenation. Halogenated polymer-coated fabrics completely inactivated human respiratory coronavirus based on a contact-killing mechanism and were shown to be reusable after recharging with bromine or chlorine.

中文翻译：

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非浸出杀菌 N-卤胺官能化聚胺、胍和乙内酰脲基涂料

具有固有抗菌特性的纤维材料有助于实时灭活微生物，实现多种用途，同时减少继发感染。含有抗病毒聚合物的涂层增强了针对现有和未来潜在流行病的表面功能。在此，我们展示了使用具有亲核双胍、胍和乙内酰脲基团的聚合物创建杀菌表面的直接途径，这些聚合物共价连接到固体支持物上。杀菌剂聚（N-乙烯基胍）（PVG）和聚（烯丙胺-co -4-氨基吡啶-co -5-（4-羟基亚苄基）乙内酰脲）（PAH）与市售聚乙烯胺（PVAm）和聚（PAH）一起引入涂料应用。 （六亚甲基双胍）（PHMB）。非浸出涂层的制备方法是首先在棉、尼龙棉和玻璃纤维织物上制备双功能硅氧烷或异氰酸酯前体涂层，然后附着聚合物。所开发的接枝方法确保了涂层的稳定性和材料的重复使用，同时保持了杀菌性能。通过次氯酸钠水溶液或原位生成次溴酸（HOBr）对聚合物涂层织物进行卤化，导致表面涂覆有高含量活性 > N-Cl 或 > N-Br 基团的 N-卤胺。聚合物涂层织物在多次洗涤循环中保持稳定，并在涂层和卤化后保持亲水特性。卤化聚合物涂层织物基于接触杀灭机制完全灭活人类呼吸道冠状病毒，并且在用溴或氯充电后可重复使用。