We herein introduce voyAGEr, an online graphical interface to explore age-related gene expression alterations in 49 human tissues. voyAGEr offers a visualisation and statistical toolkit for the finding and functional exploration of sex- and tissue-specific transcriptomic changes with age. In its conception, we developed a novel bioinformatics pipeline leveraging RNA sequencing data, from the GTEx project, encompassing more than 900 individuals. voyAGEr reveals transcriptomic signatures of the known asynchronous ageing between tissues, allowing the observation of tissue-specific age periods of major transcriptional changes, associated with alterations in different biological pathways, cellular composition, and disease conditions. Notably, voyAGEr was created to assist researchers with no expertise in bioinformatics, providing a supportive framework for elaborating, testing and refining their hypotheses on the molecular nature of human ageing and its association with pathologies, thereby also aiding in the discovery of novel therapeutic targets. voyAGEr is freely available at https://compbio.imm.medicina.ulisboa.pt/app/voyAGEr.

中文翻译：

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voyAGEr，一个免费的网络界面，用于分析人体组织中与年龄相关的基因表达变化

我们在此介绍 voyAGEr，一个在线图形界面，用于探索 49 种人体组织中与年龄相关的基因表达变化。 voyAGEr 提供了一个可视化和统计工具包，用于发现和功能探索性别和组织特异性转录组随年龄的变化。在其构想中，我们利用 GTEx 项目的 RNA 测序数据开发了一种新颖的生物信息学管道，涵盖 900 多人。 voyAGEr 揭示了组织之间已知的异步衰老的转录组特征，从而可以观察主要转录变化的组织特异性年龄阶段，这些变化与不同生物途径、细胞组成和疾病状况的变化相关。值得注意的是，voyAGEr 的创建是为了帮助没有生物信息学专业知识的研究人员，提供一个支持框架来阐述、测试和完善他们关于人类衰老的分子性质及其与病理学关系的假设，从而也有助于发现新的治疗靶点。 voyAGEr 可在 https://compbio.imm.medicina.ulisboa.pt/app/voyAGEr 免费获取。