Autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematous, are regulated by polymorphisms in genes contributing to the NOX2 complex. Mutations in both and affect development of arthritis in experimental models of RA, but the different regulatory pathways mediated by NOX2-derived reactive oxygen species (ROS) have not yet been clarified.

中文翻译：

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NCF4 通过细胞内氧化反应调节半胱氨酸肽的抗原呈递，并限制自身反应性和致关节炎 T 细胞的激活


自身免疫性疾病，例如类风湿性关节炎 (RA) 和系统性红斑狼疮，受到 NOX2 复合物基因多态性的调节。两者的突变都会影响 RA 实验模型中关节炎的发展，但 NOX2 衍生的活性氧 (ROS) 介导的不同调节途径尚未阐明。