is a devastating postharvest pathogenic fungus causing severe postharvest decay in a wide range of fruit and vegetables. Controlling postharvest pathogens is essential to the postharvest industry. Plumbagin is a plant-derived naphthoquinone compound with various pharmacological activities, such as antioxidant, anti-inflammatory, and antimicrobial effects. However, its antifungal effects on have not been fully elucidated. In this study, we investigated the antifungal activity of plumbagin against postharvest fungal pathogens and elucidated its potential mechanism on through transcriptomics. Plumbagin exhibited broad-spectrum antifungal activity and completely inhibited the growth of various postharvest pathogens at a concentration of 20 mg L. Moreover, plumbagin effectively inhibited the incidence of gray mold in grape, sweet cherry, and strawberry fruit. The spore germination and viability of were also suppressed by plumbagin. Transcriptomic analysis indicated that plumbagin significantly affected the metabolic processes and induced autophagy in . Our results suggest that plumbagin is a promising broad-spectrum plant-derived fungicide that suppresses postharvest gray mold by affecting the metabolism of and inducing autophagy. These findings provide a theoretical basis for applying plumbagin to control postharvest pathogens.

中文翻译：

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白花丹素通过影响代谢和诱导自噬来控制真菌采后病原体

是一种毁灭性的采后致病真菌，可导致多种水果和蔬菜严重采后腐烂。控制采后病原体对于采后行业至关重要。 Plumbagin 是一种植物衍生的萘醌化合物，具有多种药理活性，如抗氧化、抗炎和抗菌作用。然而，其抗真菌作用尚未完全阐明。在这项研究中，我们研究了白花丹素对采后真菌病原体的抗真菌活性，并通过转录组学阐明了其潜在机制。白花丹素具有广谱抗真菌活性，浓度为20 mg·L时，可完全抑制多种采后病原菌的生长。此外，白花丹素还能有效抑制葡萄、甜樱桃、草莓等果实灰霉病的发生。白花丹素还抑制孢子萌发和活力。转录组分析表明白花丹素显着影响代谢过程并诱导自噬。我们的结果表明，白花丹素是一种有前途的广谱植物源性杀菌剂，它通过影响代谢和诱导自噬来抑制采后灰霉病。这些研究结果为应用白花丹素控制采后病原菌提供了理论依据。