A migratory insertion of carbenes into distal γ-C(sp³)–H bonds of aliphatic amines has been successfully developed. The synergistic interplay among a palladium catalyst, picolinamide directing group, a carefully selected base additive, and an essential ligand proved crucial in achieving high yields. These findings hold significant value for advancing the exploration of regioselective carbene insertions into nonactivated C(sp³)–H bonds.

中文翻译：

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钯催化卡宾区域选择性插入脂肪胺的 γ-C(sp3)–H 键

已成功开发出卡宾迁移插入脂肪胺远端 γ-C(sp ³ )–H 键的方法。钯催化剂、吡啶酰胺导向基团、精心选择的基础添加剂和重要配体之间的协同相互作用被证明对于实现高产率至关重要。这些发现对于推进区域选择性卡宾插入非活化 C(sp ³ )–H 键的探索具有重要价值。