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Recent advances in the metal-catalyzed asymmetric alkene hydrogenation of cyclic conjugated carbonyl compounds
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2024-03-27 , DOI: 10.1039/d4qo00227j
Min Tan 1 , Bram B. C. Peters 2 , Pher G. Andersson 2, 3 , Taigang Zhou 1, 4
Affiliation  

The transition metal-catalyzed asymmetric hydrogenation of carbon–carbon double bonds is recognized as one of the most straightforward methods for the preparation of stereopure compounds. Chiral cyclic motifs have widespread applications in organic synthesis and can also be prepared via this strategy. This review summarizes the recent advances (2016–2023) in the stereoselective metal-catalyzed hydrogenation of cyclic α,β-unsaturated ketones, lactams and lactones since considerable developments in this regard were made. The applications of these methodologies in synthesis are also outlined where relevant.

中文翻译:

金属催化环状共轭羰基化合物不对称烯烃加氢研究进展

过渡金属催化的碳-碳双键不对称氢化被认为是制备立体纯化合物最直接的方法之一。手性环状基序在有机合成中具有广泛的应用,也可以通过这种策略制备。本综述总结了环α,β-不饱和酮、内酰胺和内酯的立体选择性金属催化氢化方面的最新进展(2016-2023),因为这方面取得了相当大的进展。还概述了这些方法在合成中的相关应用。
更新日期:2024-03-27
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