Despite numerous studies in the field of dementia and Alzheimer's disease (AD), a comprehensive understanding of this devastating disease remains elusive. Bulk transcriptomics have provided insights into the underlying genetic factors at a high level. Subsequent technological advancements have focused on single‐cell omics, encompassing techniques such as single‐cell RNA sequencing and epigenomics, enabling the capture of RNA transcripts and chromatin states at a single cell or nucleus resolution. Furthermore, the emergence of spatial omics has allowed the study of gene responses in the vicinity of amyloid beta plaques or across various brain regions. With the vast amount of data generated, utilizing gene regulatory networks to comprehensively study this disease has become essential. This review delves into some techniques employed in the field of AD, explores the discoveries made using these techniques, and provides insights into the future of the field.

中文翻译：

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阿尔茨海默病的基因网络和系统生物学：多组学方法的见解

尽管在痴呆症和阿尔茨海默病 (AD) 领域进行了大量研究，但对这种破坏性疾病的全面了解仍然难以实现。大量转录组学为高水平的潜在遗传因素提供了见解。随后的技术进步集中在单细胞组学上，包括单细胞 RNA 测序和表观基因组学等技术，能够以单细胞或细胞核分辨率捕获 RNA 转录本和染色质状态。此外，空间组学的出现使得研究β淀粉样斑块附近或不同大脑区域的基因反应成为可能。随着大量数据的产生，利用基因调控网络全面研究这种疾病变得至关重要。这篇综述深入研究了 AD 领域使用的一些技术，探讨了使用这些技术所取得的发现，并提供了对该领域未来的见解。