The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology. Disparities in treatment outcomes between male and female cancer patients are increasingly reported. This study aimed to examine the relationship between YBX1 expression and overall survival in male and female patients with solid tumours. Overall survival and YBX1 expression data for cohorts of male and female cancer patients obtained from freely available databases were analysed with a cox proportional hazard model with covariates of biological sex and YBX1 expression. Kaplan–Meier curves and Violin plots were constructed for segregated male and female cohorts. High YBX1 expression was significantly associated with poor survival in 2 female-only and 4 mixed-sex cancer sites. In female lung cancer patients, better survival and lower YBX1 expression were identified. The clinical importance of YBX1 expression in cancer ought to be evaluated in a sex-specific manner, especially in lung cancer.

Y-box 结合蛋白 1 ( YBX1 ) 基因编码一种多功能癌蛋白，这种蛋白越来越多地与癌细胞生物学的许多方面的调控联系起来。越来越多的报道指出，男性和女性癌症患者之间的治疗结果存在差异。本研究旨在探讨YBX1表达与男性和女性实体瘤患者总生存率之间的关系。使用具有生物性别和YBX1表达协变量的 cox 比例风险模型对从免费数据库中获得的男性和女性癌症患者队列的总生存率和YBX1表达数据进行分析。卡普兰-迈耶曲线和小提琴图是为隔离的男性和女性队列构建的。在 2 个纯女性癌症部位和 4 个混合性别癌症部位， YBX1高表达与生存率低显着相关。在女性肺癌患者中，发现了更好的生存率和更低的 YBX 1表达。 YBX1表达在癌症中的临床重要性应该以性别特异性的方式进行评估，尤其是在肺癌中。