Antiobesity effects of intestinal gluconeogenesis are mediated by the brown adipose tissue sympathetic nervous system,Obesity

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Antiobesity effects of intestinal gluconeogenesis are mediated by the brown adipose tissue sympathetic nervous system
Obesity ( IF 6.9 ) Pub Date : 2024-02-04 , DOI: 10.1002/oby.23985
Justine Vily‐Petit _{1,

2,

3} , Maud Soty‐Roca _{1,

2,

3} , Marine Silva _{1,

2,

3} , Manon Micoud _{1,

2,

3} , Félicie Evrard _{1,

2,

3} , Clara Bron _{1,

2,

3} , Margaux Raffin _{1,

2,

3} , Daniel Beiroa _{4,

5} , Rubén Nogueiras _{4,

5} , Damien Roussel _{2,

3,

6} , Amandine Gautier‐Stein _{1,

2,

3} , Fabienne Rajas _{1,

2,

3} , Daniela Cota ₇ , Gilles Mithieux _{1,

2,

3}

Affiliation

Intestinal gluconeogenesis (IGN), via the initiation of a gut-brain nervous circuit, accounts for the metabolic benefits linked to dietary proteins or fermentable fiber in rodents and has been positively correlated with the rapid amelioration of body weight after gastric bypass surgery in humans with obesity. In particular, the activation of IGN moderates the development of hepatic steatosis accompanying obesity. In this study, we investigated the specific effects of IGN on adipose tissue metabolism, independent of its induction by nutritional manipulation.

中文翻译：

肠道糖异生的抗肥胖作用是由棕色脂肪组织交感神经系统介导的

肠糖异生（IGN）通过肠-脑神经回路的启动，解释了啮齿动物中与膳食蛋白质或可发酵纤维相关的代谢益处，并且与患有胃绕道手术的人类体重的快速改善呈正相关。肥胖。特别是，IGN的激活可以减缓伴随肥胖的肝脂肪变性的发展。在这项研究中，我们研究了 IGN 对脂肪组织代谢的具体影响，独立于营养操作的诱导。

更新日期：2024-02-04

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