The Front Cover shows that ferrocene, with its hourglass-shaped structure resembling the shape of the traditional Japanese hand drum “Tsuzumi”, functions as a versatile scaffold for novel androgen receptor modulators that regulate transcription of the target genes. The substitution pattern play a key role in determining the activity mode of the compounds, i.e., agonistic or antagonistic action. More information can be found in the Research Article by Kotaro Ochiai, Ryo Yonezawa and Shinya Fujii.

中文翻译：

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封面：使用苯基二茂铁框架作为疏水药效团的雄激素受体拮抗剂的结构开发 (ChemMedChem 6/2024)

封面显示，二茂铁的沙漏形结构类似于日本传统手鼓“ Tsuzumi ”的形状，可作为调节靶基因转录的新型雄激素受体调节剂的多功能支架。取代模式在决定化合物的活性模式（即激动作用或拮抗作用）中起着关键作用。更多信息请参阅 Kotaro Ochiai、Ryo Yonezawa 和 Shinya Fujii 的研究文章。