The construction of algebraic topological framework nucleic acids (ATFNAs) provides a powerful tool to program multiple guest molecules stoichiometrically and spatially. Through the topological control of guest molecules (e. g., nucleic acids, proteins, nanoparticles and small molecules), the development of artificial clusters can be realized, able to bring tailorable functionalities that hold great promise for biological applications.

中文翻译：

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核酸代数拓扑框架的概念与发展

代数拓扑框架核酸（ATFNA）的构建提供了一种强大的工具，可以在化学计量和空间上对多个客体分子进行编程。通过客体分子（例如核酸、蛋白质、纳米颗粒和小分子）的拓扑控制，可以实现人工簇的开发，能够带来可定制的功能，为生物应用带来巨大前景。