A successful synthesis of helical-shaped axially chiral bisoxime ethers is reported. This approach utilized symmetric L-shaped diketone scaffolds as carbonyl components for the enantioselective condensation with hydroxylamines, delivering dual axially chiral oxime ethers with up to 99% ee. Additionally, the axially chiral mono-oxime ethers of azabicyclic ketones with high ee’s were also successfully produced. Various chiral bicyclic lactams can be readily synthesized via Beckmann rearrangement, demonstrating a potential application in organic synthetic chemistry.

中文翻译：

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手性磷酸催化顺序对映选择性缩合合成螺旋状轴向手性双肟醚

据报道，成功合成了螺旋形轴向手性双肟醚。该方法利用对称的 L 形二酮支架作为羰基组分，与羟胺进行对映选择性缩合，产生对映体含量高达 99% 的双轴手性肟醚。此外，还成功制备了具有高ee值的氮杂双环酮的轴向手性单肟醚。通过贝克曼重排可以很容易地合成各种手性双环内酰胺，这证明了其在有机合成化学中的潜在应用。