This study presents a novel approach for synthesizing benzo[f]isoindole dimers, which involves cascade cyclization and oxidative radical dimerization. Our method allows for the formation of up to five carbon–carbon bonds in a single reaction, exhibiting remarkable diastereoselectivity and regioselectivity. The mechanism and regioselectivity were investigated through a combination of experiments and calculations.

中文翻译：

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用于构建苯并[f]异吲哚二聚体的区域和非对映选择性自由基二聚反应

本研究提出了一种合成苯并[ f ]异吲哚二聚体的新方法，涉及级联环化和氧化自由基二聚化。我们的方法允许在单个反应中形成多达五个碳-碳键，表现出显着的非对映选择性和区域选择性。通过实验和计算相结合的方式研究了其机理和区域选择性。